They were the most prolific of many prolific singing duos that came to prominence in the 1960s. However, it was a movie that led to the breakup of Simon and Garfunkel shortly after the release of their masterpiece "Bridge Over Troubled Water". Both men had aspired to acting careers. Director Mike Nichols had cast them in key roles in his 1970 film version of Joseph Heller's anti-war novel "Catch-22". However, shortly thereafter, Nichols made the decision to cut Simon's part. Feeling hurt, Simon spent his time in New York City while Garfunkel filmed in Europe. The resentment led to Simon writing the song "The Only Living Boy in New York City", an allusion to the loneliness he felt writing the songs without the presence of his partner. Making matters worse, Garfunkel went immediately on to star in another Nichols film, Carnal Knowledge. This resulted in the duo splitting up, though they have had numerous (sometimes tension-filled) reunions in the years since. For more click here for Vanity Fair's report.